![]() This case report aims to highlight a condition in which central demyelination has been associated with bipolar disorder. This suggests different pathophysiological mechanisms in bipolar disorder and schizophrenia. In contrast with bipolar disorder, schizophrenia patients presented with alterations in both radial and axial diffusivity, suggesting increased water content outside the axonal space. 2 Disorganization in white-matter tract and myelin sheath alteration has been described in bipolar disorder. 2 Compared with healthy controls, people with bipolar disorders revealed significant abnormalities in corpus callosum, 3 deep white matter, 4 anterior-limbic neural substrate, 5 and bilateral corona radiata and right anterior thalamic radiation. 1 Prefrontal white-matter abnormalities have been found in first-episode bipolar disorder. Recent neuroimaging and neuropsychiatry research in bipolar disorders have demonstrated significant white-matter abnormalities. This case illustrated complexity in diagnosis and how a diagnosis of ALD could easily be missed. Brain imaging showed symmetrical, confluent, bilateral signal-intensity changes in the parieto-occipital deep white matter, splenium of corpus callosum, and the corticospinal tract region. He has Addison’s disease and abnormal ratio in very-long-chain fatty acid mutational analysis revealed an ABCD1 mutation. To the Editor: We reported on a young adult who presented with Bipolar I disorder and later was identified to have suffered from X-linked adrenoleukodystrophy (ALD).
0 Comments
Leave a Reply. |